![]() Some research has looked at African mango, or Irvingia gabonensis, and its proposed positive effect on leptin sensitivity and weight loss. There are many studies involving weight loss supplements, but the effect of these supplements on improving leptin resistance and appetite remains unclear ( 8, 9, 10, 11). Some feature ingredients like alpha-lipoic acid and fish oil, while others contain green tea extract, soluble fiber or conjugated linoleic acid. While numerous supplements are labeled as “leptin pills,” most contain a mix of various nutrients marketed to reduce inflammation and, therefore, increase leptin sensitivity ( 7). Most leptin supplements don’t actually contain the hormone. Therefore, increased leptin levels are not what’s important for weight loss, but improving leptin resistance may help. Leptin resistance occurs when there’s plenty of the hormone available but its signal is impaired. Therefore, taking a supplement that increases blood leptin levels does not necessarily lead to weight loss. How well your brain interprets its signal is much more significant. In terms of weight loss, more leptin is not necessarily what matters. Leptin resistance not only contributes to eating more but also signals your brain that you need to save energy, which leads you to burn calories at a slower rate ( 6). This means that even though you have more than enough of the hormone available and energy stored, your brain does not recognize it and thinks you’re still hungry. Leptin resistance occurs when your brain stops acknowledging the hormone’s signal. It would seem that higher levels would be favorable, as there would be plenty available to communicate to your brain that your body is full and cease eating. People who are obese are shown to have much higher levels of this hormone than individuals of average weight ( 4). ![]() However, in obesity, it’s not so black and white. If plenty of leptin and fat tissue are available, leptin tells the brain that your body has enough energy stored and you can stop eating.
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